Emergency Medicines

Several extracorporeal methods for the decontamination of poison have promise in emergency care settings..

TPE is performed for patients with below disorders for FASTER RECOVERY

Paraquat Poisoning

Poisonings, intoxication% and drug overdoses are common occurrences and rapid lowering of the toxin level is a cornerstone of all effective therapies. TPE has several unique characteristics that allow it to be a potentially effective therapy in rapidly achieving this goal. Specifically, TPE allows for the removal of large molecular weight, protein-bound molecules that have a small volume of distribution.

The drugs and toxicants that the study patients had been exposed to mainly included pesticides (organophosphates [OPs1, organochlorines, and pa raquat)..

TPE may also be effective in the therapy of patients receiving biologic treatments who develop life. threatening compli

Ratol Poisoning

In South India, ratol paste isa typical domestic rodenticide. Yellow phosphorus is its major component. In a rural setting, cases of suicide or accidental consumption are widespread..

Yellow phosphorus is a protoplasmic toxin affecting the hepatic, gastrointestinal, cardiovascular, and renal systems. It is slowly absorbed through the gastrointestinal tract, and respiratory mucosa and serum phosphorous levels quickly rise post consumption. The treatment for rodenticide is predominantly vitamin K supplementation. Fresh frozen plasma or prothrombin complex concentrates are needed in case of active bleeding. TPE has been studied in Long-acting Anticoagulant Rodenticide 0..AAR) poisoning. Studies have shown benefit of TPE in children following an anaphylactic reaction to vitamin K administer for brodifacoum poisoning. Many transplant centers have a protocol for 5 cycles of TPE for ALF due to yellow phosphorus poison. Such centers have done studies which have shown the benefit of plasma exchange in the setting of ALF.

Snake bite

Cytotoxins: Cause swelling and tissue damage wherever you’ve been bitten.
Haemorrhagins: Disrupt the blood vessels.
Anti-clotting agents: Prevent the blood from clotting.
Neurotoxins: Cause paralysis or other damage to the nervous system.
Myotoxins: Break down muscles.

Snake bites are leading causes of morbidity and mortality worldwide, especially in rural areas. TPE has been used in the treatment of many different conditions such as immunologic disease% toxicologic disorders, and snake envenomation. Studies had been done to evaluate the efficacy of plasma exchange treatment on clinical status, outcomes, and discharge of patients who were bitten by venomous snakes..

Plasma exchange is a nonspecific extracorporeal technique that removes offending plasma components such as metabolites, inflammatory factors, and toxic mediators, or toxins that are responsible for physical or metabolic disease,

Plasma exchange may be consider. as part of the treatment for snake bite envenomation that can be successfully treat. with conventional methods..